Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson’s Disease
Identifieur interne : 001B16 ( Main/Exploration ); précédent : 001B15; suivant : 001B17Midbrain Gene Screening Identifies a New Mesoaccumbal Glutamatergic Pathway and a Marker for Dopamine Cells Neuroprotected in Parkinson’s Disease
Auteurs : Thomas Viereckel [Suède] ; Sylvie Dumas [France] ; Casey J. A. Smith-Anttila [Suède, Australie] ; Bianca Vlcek [Suède] ; Zisis Bimpisidis [Suède] ; Malin C. Lagerström [Suède] ; Sa Konradsson-Geuken [Suède] ; Sa Wallén-Mackenzie [Suède]Source :
- Scientific Reports [ 2045-2322 ] ; 2016.
Abstract
The ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) of the midbrain are associated with Parkinson’s disease (PD), schizophrenia, mood disorders and addiction. Based on the recently unraveled heterogeneity within the VTA and SNc, where glutamate, GABA and co-releasing neurons have been found to co-exist with the classical dopamine neurons, there is a compelling need for identification of gene expression patterns that represent this heterogeneity and that are of value for development of human therapies. Here, several unique gene expression patterns were identified in the mouse midbrain of which
Url:
DOI: 10.1038/srep35203
PubMed: 27762319
PubMed Central: 5071886
Affiliations:
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A." last="Smith-Anttila">Casey J. A. Smith-Anttila</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Organismal Biology/Comparative Physiology, Uppsala University</institution>, S-752 36 Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a4"><institution>Department of Anatomy and Neuroscience, University of Melbourne</institution>, Victoria 3010,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vlcek, Bianca" sort="Vlcek, Bianca" uniqKey="Vlcek B" first="Bianca" last="Vlcek">Bianca Vlcek</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Organismal Biology/Comparative Physiology, Uppsala University</institution>, S-752 36 Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bimpisidis, Zisis" sort="Bimpisidis, Zisis" uniqKey="Bimpisidis Z" first="Zisis" last="Bimpisidis">Zisis Bimpisidis</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Organismal Biology/Comparative Physiology, Uppsala University</institution>, S-752 36 Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lagerstrom, Malin C" sort="Lagerstrom, Malin C" uniqKey="Lagerstrom M" first="Malin C." last="Lagerström">Malin C. Lagerström</name><affiliation wicri:level="1"><nlm:aff id="a2"><institution>Department of Neuroscience, Uppsala University</institution>, S-751 24 Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konradsson Geuken, Sa" sort="Konradsson Geuken, Sa" uniqKey="Konradsson Geuken " first=" Sa" last="Konradsson-Geuken"> Sa Konradsson-Geuken</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Organismal Biology/Comparative Physiology, Uppsala University</institution>, S-752 36 Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wallen Mackenzie, Sa" sort="Wallen Mackenzie, Sa" uniqKey="Wallen Mackenzie " first=" Sa" last="Wallén-Mackenzie"> Sa Wallén-Mackenzie</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Organismal Biology/Comparative Physiology, Uppsala University</institution>, S-752 36 Uppsala,<country>Sweden</country></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) of the midbrain are associated with Parkinson’s disease (PD), schizophrenia, mood disorders and addiction. Based on the recently unraveled heterogeneity within the VTA and SNc, where glutamate, GABA and co-releasing neurons have been found to co-exist with the classical dopamine neurons, there is a compelling need for identification of gene expression patterns that represent this heterogeneity and that are of value for development of human therapies. Here, several unique gene expression patterns were identified in the mouse midbrain of which <italic>NeuroD6</italic> and <italic>Grp</italic> were expressed within different dopaminergic subpopulations of the VTA, and <italic>TrpV1</italic> within a small heterogeneous population. Optogenetics-coupled <italic>in vivo</italic> amperometry revealed a previously unknown glutamatergic mesoaccumbal pathway characterized by <italic>TrpV1-Cre</italic>-expression. Human GRP was strongly detected in non-melanized dopaminergic neurons within the SNc of both control and PD brains, suggesting GRP as a marker for neuroprotected neurons in PD. This study thus unravels markers for distinct subpopulations of neurons within the mouse and human midbrain, defines unique anatomical subregions within the VTA and exposes an entirely new glutamatergic pathway. Finally, both TRPV1 and GRP are implied in midbrain physiology of importance to neurological and neuropsychiatric disorders.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bromberg Martin, E S" uniqKey="Bromberg Martin E">E. S. Bromberg-Martin</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M. Matsumoto</name></author><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O. Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dahlstrom, A" uniqKey="Dahlstrom A">A. Dahlström</name></author><author><name sortKey="Fuxe, K" uniqKey="Fuxe K">K. 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Mishra</name></author><author><name sortKey="Harrison, N R" uniqKey="Harrison N">N. R. Harrison</name></author><author><name sortKey="Gonzales, C B" uniqKey="Gonzales C">C. B. Gonzales</name></author><author><name sortKey="Schilstrom, B" uniqKey="Schilstrom B">B. Schilström</name></author><author><name sortKey="Konradsson Geuken, " uniqKey="Konradsson Geuken ">Å. Konradsson-Geuken</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Viereckel, Thomas" sort="Viereckel, Thomas" uniqKey="Viereckel T" first="Thomas" last="Viereckel">Thomas Viereckel</name></noRegion><name sortKey="Bimpisidis, Zisis" sort="Bimpisidis, Zisis" uniqKey="Bimpisidis Z" first="Zisis" last="Bimpisidis">Zisis Bimpisidis</name><name sortKey="Konradsson Geuken, Sa" sort="Konradsson Geuken, Sa" uniqKey="Konradsson Geuken " first=" Sa" last="Konradsson-Geuken"> Sa Konradsson-Geuken</name><name sortKey="Lagerstrom, Malin C" sort="Lagerstrom, Malin C" uniqKey="Lagerstrom M" first="Malin C." last="Lagerström">Malin C. Lagerström</name><name sortKey="Smith Anttila, Casey J A" sort="Smith Anttila, Casey J A" uniqKey="Smith Anttila C" first="Casey J. A." last="Smith-Anttila">Casey J. A. Smith-Anttila</name><name sortKey="Viereckel, Thomas" sort="Viereckel, Thomas" uniqKey="Viereckel T" first="Thomas" last="Viereckel">Thomas Viereckel</name><name sortKey="Vlcek, Bianca" sort="Vlcek, Bianca" uniqKey="Vlcek B" first="Bianca" last="Vlcek">Bianca Vlcek</name><name sortKey="Wallen Mackenzie, Sa" sort="Wallen Mackenzie, Sa" uniqKey="Wallen Mackenzie " first=" Sa" last="Wallén-Mackenzie"> Sa Wallén-Mackenzie</name></country><country name="France"><noRegion><name sortKey="Dumas, Sylvie" sort="Dumas, Sylvie" uniqKey="Dumas S" first="Sylvie" last="Dumas">Sylvie Dumas</name></noRegion></country><country name="Australie"><noRegion><name sortKey="Smith Anttila, Casey J A" sort="Smith Anttila, Casey J A" uniqKey="Smith Anttila C" first="Casey J. A." last="Smith-Anttila">Casey J. A. Smith-Anttila</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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